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The Role of Collagen in Energy Metabolism and Physical Vitality

The Role of Collagen in Energy Metabolism and Physical Vitality

Collagen, a primary structural protein found abundantly in the human body, is traditionally recognised for its critical roles in skin elasticity, joint health, and tissue repair. Recent scientific studies, however, have started to unveil collagen's significant influence on energy metabolism and overall vitality. This article explores the biochemical pathways through which collagen contributes to energy production, muscle health, and metabolic efficiency, thereby underscoring its potential as a key nutrient in enhancing physical energy and endurance.


Energy metabolism is a fundamental process for human health and performance, involving the conversion of food into usable energy. Proteins, as part of the macronutrients consumed in the diet, play a vital role in this process. Collagen, making up approximately 30% of the total protein in the human body, serves not only as a structural component but also as a significant contributor to metabolic health and energy production. This article reviews the current scientific literature on collagen's role in energy metabolism, focusing on its impact on muscle maintenance, gut health, and metabolic function.

Collagen's Role in Muscle Health and Energy Production

  1. Muscle Maintenance and Metabolism: Collagen contains a unique composition of amino acids, such as glycine, proline, and hydroxyproline, which are essential for the synthesis and repair of muscle tissue. Muscle tissue is a critical component of the body's energy metabolism, as it is a significant site for glucose uptake and resting energy expenditure. Studies have shown that collagen supplementation can help maintain lean muscle mass and promote muscle health, which in turn supports a more efficient metabolic rate and energy production (Zdzieblik et al., 2015).

  2. Amino Acids and Energy Production: The amino acids in collagen play direct and indirect roles in energy metabolism. Glycine, for instance, is involved in the synthesis of creatine, which supplies energy to muscles during high-intensity, short-duration exercises (Brosnan and Brosnan, 2016). Moreover, proline and hydroxyproline can be converted into glucose via gluconeogenesis, providing an additional energy source during prolonged exercise or fasting periods.

Collagen and Gut Health: Implications for Energy Metabolism

  1. Gut Barrier Function and Nutrient Absorption: Collagen's role in supporting gut health is another pathway through which it influences energy metabolism. Collagen peptides can contribute to the integrity of the gut lining, potentially preventing leaky gut syndrome—a condition that can impair nutrient absorption and lead to inflammation, further draining the body's energy resources (Chen et al., 2017).

  2. Anti-inflammatory Properties: Chronic inflammation can lead to metabolic disturbances and decreased energy levels. Collagen, particularly through its glycine content, exhibits anti-inflammatory properties that may help reduce systemic inflammation and support metabolic health, thereby potentially improving energy availability and utilisation (Li and Wu, 2018).

Metabolic Efficiency and Collagen Supplementation

  1. Collagen's Impact on Metabolism: Collagen supplementation has been associated with an increase in basal metabolic rate (BMR), possibly through its effects on muscle mass and gut health. An elevated BMR means the body can burn more calories at rest, contributing to improved energy levels and reduced fat accumulation (Tomé et al., 2019).

  2. Clinical Studies and Evidence: Clinical trials have begun to explore the effects of collagen supplementation on energy metabolism. For example, a study by Zdzieblik et al. (2015) found that collagen peptide supplementation in combination with resistance training significantly increased lean body mass and muscle strength, indicative of enhanced metabolic health and energy production capabilities.


Collagen plays a multifaceted role in supporting energy metabolism and physical vitality, primarily through its contributions to muscle maintenance, gut health, and metabolic efficiency. While further research is needed to fully understand the mechanisms and optimise the use of collagen for energy support, current evidence suggests that collagen supplementation is a valuable strategy for enhancing metabolic health, energy production, and overall physical performance. As the scientific community continues to explore the potential health benefits of collagen, its role in supporting a vibrant, energetic life becomes increasingly apparent.


  • Zdzieblik, D., Oesser, S., Baumstark, M.W., Gollhofer, A., König, D. (2015). Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: A randomised controlled trial. British Journal of Nutrition, 114(8), 1237-1245.
  • Brosnan, J.T., Brosnan, M.E. (2016). The role of dietary creatine. Amino Acids, 48(8), 1785–1791.
  • Chen, Q., Chen, O., Martins, I.M., Hou, H., Zhao, X., Blumberg, J


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